Uptown neighborhoods
| Name of the neighborhood | Limits south to north and east to west |
| Upper Manhattan | Above 96th Street |
| Marble Hill | Physically located on the mainland |
| Inwood | Above Dyckman Street |
| Fort George (part of Washington Heights) | East of Broadway between 181st Street and Dyckman Street |
| Washington Heights | 155th Street to Dyckman Street |
| Hudson Heights (part of Washington Heights) | 181st Street to Fort Tryon Park west of Broadway |
| West Harlem | 125th to 155th Streets; St. Nicholas Avenue to Broadway |
| Hamilton Heights (part of Harlem) | 135th to 155th Streets; Broadway to the Hudson River |
| Manhattanville | 125th to 135th Streets; St. Nicholas Avenue to the Hudson River |
| Morningside Heights | 110th to 125th Streets; Morningside to Riverside Drive |
| Central Harlem | 110th to 155th Streets; Park to St. Nicholas Avenues |
| Harlem | 96th to 141st Streets (east), 110th to 155th Streets (central), 125th to 155th Streets (west) |
| St. Nicholas Historic District, aka Strivers’ Row (Central Harlem) | 137th to 138th Streets; 7th to 8th Avenues |
| Astor Row (Central Harlem) | Centered at West 130th Street |
| Sugar Hill (Central Harlem) | 145th to 155th Streets; Edgecombe to Amsterdam Avenues |
| Marcus Garvey Park, Mount Morris Historical District | 120th to 124th Streets; Madison to 5th Avenues |
| Le Petit Senegal (Little Senegal) | 116th Street east of Morningside Park |
| East Harlem (Spanish Harlem) | 96th to 141st Streets; the East River to 5th Avenue |
| Upper East Side | East 59th to 96th Streets; the East River to 5th Avenue (and 96th to 110th Streets along 5th Avenue) |
| Lenox Hill | 60th to 77th Streets; the East River to Park Avenue |
| Carnegie Hill | 86th to 98th Streets; 3rd to 5th Avenues (centered at East 91st Street and Park Avenue) |
| Yorkville | 79th to 96th Street; the East River to 3rd Avenue (centered at East 86th Street and 3rd Avenue) |
| Upper West Side | 59th to 110th Streets; Central Park West to the Hudson River |
| Manhattan Valley, Bloomingdale District | 96th to 110th Streets; Central Park West to Broadway |
| Lincoln Square (once San Juan Hill) | 59th to 66th Streets; Columbus Avenue to Broadway |
Midtown neighborhoods
| Name of the neighborhood | Limits south to north and east to west |
| Midtown | 34th to 59th Streets |
| Columbus Circle | 59th Street and 8th Avenue |
| Sutton Place | 53rd to 59th Streets; 1st Avenue to Sutton Place |
| Rockefeller Center | 49th to 51st Streets; 5th to 6th Avenues |
| Diamond District | 47th Street from 5th to 6th Avenues |
| Theater District | 42nd to 53rd Streets; 6th to 8th Avenues |
| Turtle Bay | 42nd to 53rd Streets; East River to Lexington Avenue |
| Midtown East | 42nd to 59th Streets; East River to 5th Avenue |
| Midtown | 40th to 59th Streets; 3rd to 9th Avenues |
| Tudor City | 40th to 43rd Streets; 1st to 2nd Avenues |
| Little Brazil | 46th Street from 5th to 6th Avenues |
| Times Square | 39th to 52nd Streets; 7th to 9th Avenues |
| Hudson Yards | 28th to 43rd Streets; 7th Avenue to the Hudson River |
| Midtown West | 34th to 59th Streets; 5th Avenue to the Hudson River |
| Hell’s Kitchen | 34th to 59th Streets; 8th to the Hudson River |
| Garment District | 34th to 42nd Streets and 5th to 9th Avenues |
| Herald Square | 34th Street and 6th Avenue |
| Koreatown | 31st to 36th Streets; 5th to 6th Avenues |
| Murray Hill aka Curry Hill aka Little India (former Little Armenia)[1][2] | 34th to 40th Streets; 3rd to Madison Avenues |
| Tenderloin | 23rd Street to 42nd Streets; 5th to 7th Avenues |
| Madison Square | 23rd to 26th Streets; 5th Avenue to Broadway |
Between Midtown and Downtown
| Name of the neighborhood | Limits south to north and east to west |
| Flower District[3][4][5] | 26th to 28th Streets; 6th to 7th Avenues |
| Brookdale | 25th Street from FDR Drive to 1st Avenue |
| Hudson Yards | 30th to 34th Streets; the Hudson River to Tenth Avenue |
| Kips Bay | 23rd to 34th Streets; the East River to 3rd Avenue |
| Rose Hill | Between Murray Hill to the north and Gramercy Park to the south |
| NoMad | East 25th Street to East 29th Street; Madison Avenue to Sixth Avenue[6] |
| Peter Cooper Village† (former Gas House district) | 20th to 23rd Streets; Avenue C to 1st Avenue |
| Chelsea | 14th to 34th Streets; 6th Avenue to the Hudson River |
| Flatiron District, Toy District, Photo District | 16th to 27th Streets; Park Avenue South to 6th Avenue |
| Gramercy Park | 14th to 23rd Streets; 1st Avenue to Park Avenue South |
| Stuyvesant Square | 15th to 18th Streets; 1st to 3rd Avenues |
| Union Square | 14th to 17th Streets; 4th Avenue to University Place |
| Stuyvesant Town† (former Gas House district) | 14th to 20th Streets; Avenue C to 1st Avenue |
| Meatpacking District | Horatio to 15th Streets; Hudson Street to the Hudson River |
| Waterside Plaza | 25th to 29th Streets; the East River to FDR Drive |
†Large scale developments
Downtown neighborhoods
| Name of the neighborhood | Limits south to north and east to west |
| Downtown Manhattan | Below 14th Street |
| Little Germany (historic) | 7th to 10th Streets; Avenues A to B |
| Alphabet City and Loisaida | Houston to 14th Streets; FDR Drive to Avenue A |
| East Village | Houston to 14th Streets; the East River to the Bowery |
| Greenwich Village | Houston to 14th Streets; Broadway to the Hudson River |
| NoHo | Houston Street to Astor Place; the Bowery to Broadway |
| Bowery | Canal to 4th Streets; the Bowery |
| West Village | Houston to 14th Streets; 6th Avenue (or 7th Avenue) to the Hudson River |
| Lower East Side | Canal to Houston Streets; the East River to the Bowery |
| SoHo | Canal to Houston Streets; Lafayette to Varick Streets |
| Nolita (NoLIta) | Broome to Houston Streets; the Bowery to Lafayette Street |
| Little Australia | Mulberry Street in Nolita |
| Little Italy | Mulberry Street from Canal to Broome Streets |
| Chinatown | Chambers to Delancey Streets; East Broadway to Broadway |
| Financial District | Below Chambers Street |
| Five Points (historic) | Worth and Baxter Streets |
| Cooperative Village† | Frankfort to Grand Streets; FDR Drive to East Broadway |
| Two Bridges | Brooklyn Bridge to Montgomery Street; St. James Place to the East River |
| Tribeca (TriBeCa) | Vesey Street to Canal Street; Broadway to the Hudson River |
| Civic Center | Vesey to Chambers Streets; the East River to Broadway |
| Radio Row (historic) | Greenwich Street from Cortlandt to Dey Streets (World Trade Center site) |
| South Street Seaport Historical District | South of Fulton Street and along the FDR Drive |
| Battery Park City† | West of West Street |
| Little Syria (historic) | Washington Street from Battery Park to above Rector Street |